Lemon Skunk is an award-winning sativa hybrid, celebrated for its lemon flavour and a THC count as high as 22%. It made the High Times list of top 10 strains in 2009. Developed by DNA Genetics, Lemon Skunk is bred from two different strains of skunk, each with a strong lemon scent and flavour. The mother originates from Vegas, while the father comes from Holland.

Its effects begin with a surge of uplifting cerebral stimulation, often leading to introspection. Many describe this strain as thought-provoking and creativity-inducing, with exhilarating and energetic properties. However, the numbing and calming effects can cause users to feel slightly sedated. Inexperienced users may find it puts them to sleep an hour or two after the initial cerebral stimulation wears off. Common negative effects include dry mouth and eyes, possible paranoia, anxiety, and dizziness, especially at higher doses.

Lemon Skunk performs well for daytime pain relief, particularly for chronic migraines, and is often prescribed for this purpose. Those suffering from stress, anxiety, and depression favour this strain for its mood-elevating properties. It is also used to relieve nausea and eating disorders.